Causality of Aging Hallmarks
An integrative framework examining the causal relationships between aging mechanisms and established aging hallmarks.
2026 Framework Integration: Toward a Unified Understanding of Aging Mechanisms
The 2026 framework integration work places aging hallmarks within the Integrated Aging Theory Framework as downstream manifestations of fundamental aging mechanisms.
It examines causal relationships between core aging mechanisms and the phenotypes commonly described as hallmarks of aging.
This publication represents the latest theoretical development of BHIAR and extends the framework toward a unified understanding of aging mechanisms.
Telomere/rDNA shortening → p53 upregulation → Cellular senescence → Aging hallmarks
